Fig. 1: 4-OI significantly alleviates sepsis-induced ALI in vivo. | Cell Death Discovery

Fig. 1: 4-OI significantly alleviates sepsis-induced ALI in vivo.

From: Itaconate inhibits ferroptosis of macrophage via Nrf2 pathways against sepsis-induced acute lung injury

Fig. 1

A Representative images of H&E and Masson staining of lung tissue. Morphology was examined using light microscopy. B Semiquantitative histological scores of lung injury in groups described in panel (n = 6). C Lung wet-to-dry weight ratio and was determined in all groups (n = 6). D ELISA for TNF-α, IL-1β and IL-6 in murine lung tissue (n = 6). E–G Relative levels of TNF-α, IL-1β and IL-6 mRNAs in murine lung tissue (n = 6). H Representative images of immunofluorescence staining for CD68 and DAPI in lung tissue. (Data are presented as Mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001).

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