Fig. 7: A schematic diagram of lncRNA TRERNA1 functions in DLBCL.

ALKBH5-mediated upregulation of TRERNA1 with a low level of m⁶A modification can promote cell proliferation and cell cycle progression. The m⁶A modification of TRERNA1 was shown to epigenetically silence p21 transcription to accelerate cell cycle progression by interacting with EZH2.