Fig. 3: MSC–EVs carrying miR-181a–2–3p inhibit apoptosis and OS of SH-SY5Y cells. | Cell Death Discovery

Fig. 3: MSC–EVs carrying miR-181a–2–3p inhibit apoptosis and OS of SH-SY5Y cells.

From: MicroRNA-181a–2–3p shuttled by mesenchymal stem cell-secreted extracellular vesicles inhibits oxidative stress in Parkinson’s disease by inhibiting EGR1 and NOX4

Fig. 3

A miR-181a–2–3p expression determined by RT-qPCR. B Cell proliferation in SH-SY5Y cells co-incubated with MSC–EVs. C Apoptosis of SH-SY5Y cells co-incubated with MSC–EVs. D SOD level in SH-SY5Y cells co-incubated with MSC–EVs using SOD kit. E MDA level in SH-SY5Y cells co-incubated with MSC–EVs using MDA kit. F ROS levels in SH-SY5Y cells co-incubated with MSC-EVs using DCFH-DA fluorescent staining. *p < 0.05 vs. MSC–EV–NC mimic or SH-SY5Y cells without treatment, #p < 0.05 vs. 6-OHDA-induced SH-SY5Y cells; $p < 0.05 vs. SH-SY5Y cells co-incubated with MSC–EV–NC mimic. Cell experiments were repeated three times independently.

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