Fig. 7: p38 MAPK pathway mediates NOX4 to promote apoptosis and OS of SH-SY5Y cells. | Cell Death Discovery

Fig. 7: p38 MAPK pathway mediates NOX4 to promote apoptosis and OS of SH-SY5Y cells.

From: MicroRNA-181a–2–3p shuttled by mesenchymal stem cell-secreted extracellular vesicles inhibits oxidative stress in Parkinson’s disease by inhibiting EGR1 and NOX4

Fig. 7

A MEM analysis of NOX4 and p38 MAPK significant co-expression. B The levels of NOX4, p–p38, and p38 in SH-SY5Y cells after different treatments measured by Western blot assay. C Cell proliferation in SH-SY5Y cells after different treatments. D Cell apoptosis in SH-SY5Y cells after different treatments. E SOD level in SH-SY5Y cells after different treatments. F MDA level in SH-SY5Y cells after different treatments. G ROS levels in SH-SY5Y cells after different treatments detected using DCFH-DA fluorescent staining. *p < 0.05 vs. SH-SY5Y cells without treatment, #p < 0.05 vs. oe-NC + DMSO; $p < 0.05 vs. oe-NOX4 + DMSO. Cell experiments were repeated three times independently.

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