Fig. 8: Dynamic cellular changes during FHP.

We identified unique cell subpopulations including KRT17^high basal-like epithelial cells, FN1^high macrophages, PLA2G7^high macrophages, MS4A6A^high macrophages, ACTA2^high fibroblasts, COL1A1^high fibroblasts, TCF21^high fibroblasts, and PLA2G2A^high fibroblasts in FHP lungs. We also observed an expansion of NK cells and CD8⁺ T cells during FHP. These subpopulations are potentially key players for FHP pathogenesis.