Fig. 5: ECM1-HF-MSCs inhibit the TGF-β/Smad signaling pathway and activation of HSCs in vitro. | Cell Death Discovery

Fig. 5: ECM1-HF-MSCs inhibit the TGF-β/Smad signaling pathway and activation of HSCs in vitro.

From: ECM1 modified HF-MSCs targeting HSC attenuate liver cirrhosis by inhibiting the TGF-β/Smad signaling pathway

Fig. 5: ECM1-HF-MSCs inhibit the TGF-β/Smad signaling pathway and activation of HSCs in vitro.

A The quiescent murine hepatic stellate cell line JS1. B Activated JS1 cells. Scale bar  = 50  μm. C Western blotting analysis of a-SMA, TGF-β, and p-Smad2/3 in all groups. D–F Semiquantitative analysis of the pathway proteins and a-SMA. Data are shown as the means ± SDs (*p  <  0.05, **p  <  0.01, ***p  < 0.001).

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