Fig. 1: Cannabinoids and cannabis extracts modulate the expression of ACE2 and TMPRSS2 in WI-38 cells.
From: New AKT-dependent mechanisms of anti-COVID-19 action of high-CBD Cannabis sativa extracts
A Western blot analysis of ACE2, CB1R and CB2R in the indicated cell lines, GAPDH served as a loading control. B, C Western blot analysis of ACE2 (B) and TMPRSS2 (C) in WI-38 cells treated with the indicated cannabinoids; relative densitometry was determined using ImageJ. D Western blot analysis of the indicated proteins in WI-38 cells treated with either CBD or the indicated cannabis extracts; relative densitometry was measured using ImageJ. E Western blot analysis of ACE2 and TMPRSS2 in WI-38 cells treated with the indicated extracts; relative densitometry was measured using ImageJ. * indicates p < 0.05; # indicates p < 0.001.
