Fig. 7: DMF alleviated renal injury in CS-AKI mice. | Cell Death Discovery

Fig. 7: DMF alleviated renal injury in CS-AKI mice.

From: Myoglobin promotes macrophage polarization to M1 type and pyroptosis via the RIG-I/Caspase1/GSDMD signaling pathway in CS-AKI

Fig. 7

a Schematic diagram of experimental design of DMF treatment for CS-AKI mice. b, c qPCR analyses KIM-1 and NGAL mRNA level in the renal tissues of four groups (NC, CS, CS + DMF, DMF). d–g Concentration of biochemical indicators CK, myoglobin, SCr and BUN in serum. h Evaluation of the therapeutic effect of DMF on the kidney tissue of CS-AKI mice by HE staining (original magnification: 200×, scale bar: 100 μm). i IHC staining analyses the expression of NGAL in kidney tissues (original magnification: 200×, scale bar: 100 μm). For statistical analysis, one-way ANOVA followed by Tukey’s method for multiple comparisons used in (b–g). Data are expressed as mean ± SD, n = 3 per group. **P < 0.01, ***P < 0.001.

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