Fig. 4: rhJAG1 or rhFASLG treatment controls NOTCH signaling activation. | Cell Death Discovery

Fig. 4: rhJAG1 or rhFASLG treatment controls NOTCH signaling activation.

From: FAS receptor regulates NOTCH activity through ERK-JAG1 axis activation and controls oral cancer stemness ability and pulmonary metastasis

Fig. 4

A rhJAG1 (0.25 ng/mL) or rhFASLG (0.25 ng/mL) treatment promotes NOTCH1 signaling activation. B NOTCH signaling pathway activation analysis by cleavage NOTCH1 expression under rhJAG1 or rhFASLG treatment. C Knockdown of JAG1 or NOTCH1 by shRNA suppresses NOTCH1-ICD cleavage. D The CSC sphere formation assay in JAG1- or NOTCH1-silenced SAS cells. E, F JAG1 Kaplan–Meier plots of OS for the Taiwanese OSCC cohort (E, GSE37991) and the TCGA-HNSC cohort (F).

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