Fig. 7: The FAS receptor regulates JAG1 expression in OSCC through ERK activation. | Cell Death Discovery

Fig. 7: The FAS receptor regulates JAG1 expression in OSCC through ERK activation.

From: FAS receptor regulates NOTCH activity through ERK-JAG1 axis activation and controls oral cancer stemness ability and pulmonary metastasis

Fig. 7

A–C ERK inhibitor (PD98059 10 μM) treatment inhibited ERK phosphorylation (A), JAG1 expression (B), and NOTCH1 cleavage (C). D Hypothetical model showing how FAS controls OSCC distant pulmonary metastasis via the activation of ERK-JAG1- NOTCH1.

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