Fig. 2: Edonerpic maleate preserves intracellular Ca2+ homeostasis and regulates glutamate receptors. | Cell Death Discovery

Fig. 2: Edonerpic maleate preserves intracellular Ca2+ homeostasis and regulates glutamate receptors.

From: Edonerpic maleate regulates glutamate receptors through CRMP2- and Arc-mediated mechanisms in response to brain trauma

Fig. 2

A Edonerpic maleate alleviated the intracellular Ca2+ concentration within 30 min following TNI and glutamate treatment. #p < 0.05 vs. Control. *p < 0.05 vs. TNI + glutamate. B Edonerpic maleate attenuated NMDA-induced Ca2+ response within 15 min. #p < 0.05 vs. Control. *p < 0.05 vs. NMDA. C Edonerpic maleate attenuated AMPA-induced Ca2+ response within 15 min. #p < 0.05 vs. Control. *p < 0.05 vs. AMPA. D Edonerpic maleate did not alter NR2A expression. E Edonerpic maleate reduced surface NR2B expression. F Edonerpic maleate decreased total and surface GluR1 expression. G Edonerpic maleate did not alter GluR2 expression. #p < 0.05 vs. Control. Error bars indicate SEM.

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