Fig. 6: MiR-17-5p targets SPOP. | Cell Death Discovery

Fig. 6: MiR-17-5p targets SPOP.

From: Tumor stem cell-derived exosomal microRNA-17-5p inhibits anti-tumor immunity in colorectal cancer via targeting SPOP and overexpressing PD-L1

Fig. 6

A SPOP expression in CRC tissues and adjacent normal tissues detected using RT-qPCR (n = 70); B SPOP expression in CRC tissues and paracancerous tissues detected using western blot analysis (n = 70); C correlation between expression of miR-17-5p and SPOP analyzed using Pearson test (n = 70); D binding sites between miR-17-5p and SPOP predicted at a bioinformatic website; E targeting relationship between miR-17-5p and SPOP confirmed using dual-luciferase reporter gene assay; F targeting relationship between miR-17-5p and SPOP confirmed using RIP assay; G SPOP expression in HCT116 cells detected using RT-qPCR and western blot analysis. Cell experiments were repeated three times; *P < 0.05 vs the miR-17-5p-NC-Exo group; the measurement data were expressed as mean ± standard deviation.

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