Fig. 8: MiR-17-5p targets SPOP to upregulate PD-L1, thus affecting the anti-tumor immunity in CRC cells. | Cell Death Discovery

Fig. 8: MiR-17-5p targets SPOP to upregulate PD-L1, thus affecting the anti-tumor immunity in CRC cells.

From: Tumor stem cell-derived exosomal microRNA-17-5p inhibits anti-tumor immunity in colorectal cancer via targeting SPOP and overexpressing PD-L1

Fig. 8

A, B PD-L1 expression in HCT116 expression detected using western blot analysis after treatment with miR-17-5p-mimic/inhibitor- Exo; C SPOP and PD-L1 levels examined using immunohistochemistry after treatment with miR-17-5p-mimic/inhibitor -Exo (n = 5); cell experiments were repeated three times and there were 5 mice in each group; *P < 0.05 vs the PBS group, #P < 0.05 vs the miR-17-5p-NC-Exo group, &P < 0.05 vs the pcDNA-NC group; the measurement data were expressed as mean ± standard deviation.

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