Fig. 6: Smurf2 degrades SMAD2 to prevent the activation of NANOG and DNMT1 and hence to reduce epidermal wound healing in mice. | Cell Death Discovery

Fig. 6: Smurf2 degrades SMAD2 to prevent the activation of NANOG and DNMT1 and hence to reduce epidermal wound healing in mice.

From: Smurf2-induced degradation of SMAD2 causes inhibition of hair follicle stem cell differentiation

Fig. 6

A Smurf2, SMAD2, NANOG and DNMT1 protein levels in the wounded tissues from mice on day 10 measured by western blot assay. B Representative images of wound area in mice on the days 0, 6, 10, and 14. C Wound healing area in mice on the days 0, 6, 10, and 14. D Protein expression of growth factors TGF-β1, VEGF, PDGF-BB, KRT5 and KRT10 in the wounded tissues from mice measured by western blot assay. E Smurf2, SMAD2, NANOG and DNMT1 protein levels in the wounded tissues from mice on day 18 measured by western blot assay. *p < 0.05 vs. oe-NC group; #p < 0.05 vs. oe-Smurf2 + oe-NC group. Data are expressed as mean ± standard deviation. Data between multiple groups were compared by one-way ANOVA with Tukey’s post hoc test. n = 6.

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