Fig. 3: Stattic induces apoptosis of PCCs via a cleaved-caspase-3-dependent mechanism. | Cell Death Discovery

Fig. 3: Stattic induces apoptosis of PCCs via a cleaved-caspase-3-dependent mechanism.

From: Inhibition of STAT3Y705 phosphorylation by Stattic suppresses proliferation and induces mitochondrial-dependent apoptosis in pancreatic cancer cells

Fig. 3

PCCs were treated with 4 and 10 μM of Stattic for 24 h. A, B Apoptosis of Stattic-treated BxPc-3 and PANC-1 cells. C, D Expression of full-length caspase-3 (FL-Casp3) and cleaved caspase-3 (CL-Casp3) in Stattic-treated PANC-1 and BxPc-3 cells. E, F Immunocytochemical staining of cleaved caspase-3 in Stattic-treated PANC-1 and BxPc-3 cells. Bar = 50 μm. *P < 0.05, ***P < 0.001.

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