Fig. 4: Stattic induces apoptosis of PCCs via a mitochondrial-dependent pathway. | Cell Death Discovery

Fig. 4: Stattic induces apoptosis of PCCs via a mitochondrial-dependent pathway.

From: Inhibition of STAT3Y705 phosphorylation by Stattic suppresses proliferation and induces mitochondrial-dependent apoptosis in pancreatic cancer cells

Fig. 4

PCCs were treated with 4 and 10 μM of Stattic for 24 h. A, B Expression of Bax, Bcl-2, and cytochrome C in Stattic-treated PANC-1 and BxPc-3 cells. C–E Immunocytochemical staining for Bcl-2, Bax, and cytochrome C in Stattic-treated PANC-1 and BxPc-3 cells. Bar = 50 μm. F Expression of cleaved PARP (CL-PARP), cleaved caspase-8 (CL-Casp8), and full-length caspase-8 (FL-Casp8). G Expression of survivin in Stattic-treated BxPc-3 and PANC-1 cells. *P < 0.05, **P < 0.01, ***P < 0.001.

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