Fig. 5: Stattic selectively antagonizes STAT3Y705 phosphorylation and inactivates STAT3 in PCCs. | Cell Death Discovery

Fig. 5: Stattic selectively antagonizes STAT3Y705 phosphorylation and inactivates STAT3 in PCCs.

From: Inhibition of STAT3Y705 phosphorylation by Stattic suppresses proliferation and induces mitochondrial-dependent apoptosis in pancreatic cancer cells

Fig. 5

PCCs were treated with 4 and 10 μM of Stattic for 24 h. A, B Expression and phosphorylation of JAK2 and STAT3 in Stattic-treated BxPc-3 and PANC-1 cells. C, D Immunocytochemical staining of p-JAK2 and p-STAT3 in Stattic-treated PANC-1 and BxPc-3 cells. Bar = 50 μm. E, F Expression and phosphorylation of STAT3 in different PCCs. Data are shown as the mean ± standard deviation. ***P < 0.001.

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