Fig. 1: METTL3 was highly expressed in OS tissues and cells and correlated with the prognosis and clinicopathological features of OS patients. | Cell Death Discovery

Fig. 1: METTL3 was highly expressed in OS tissues and cells and correlated with the prognosis and clinicopathological features of OS patients.

From: METTL3 stabilizes HDAC5 mRNA in an m6A-dependent manner to facilitate malignant proliferation of osteosarcoma cells

Fig. 1

A, B METTL3 expression in 50 pairs of OS tissues and adjacent tissues was detected using RT-qPCR and western blot. C, D METTL3 expression in human OS cell lines (U2OS, HOS, SAOS2) and normal osteoblasts (hFOB1.1) was detected using RT-qPCR and western blot. E With the median mRNA level of METTL3 in OS tissues as the critical value, the correlation between METTL3 mRNA level and prognosis of 50 OS patients was analyzed using Kaplan–Meier survival curve. N = 50. The cell experiment was repeated three times independently. Data in panels B–D are presented as mean ± standard deviation. Data in panel A were analyzed using paired t-test and data in panel B were analyzed using t-test. Data comparisons between two groups in panel E were analyzed using Log-Rank test and data comparisons among multiple groups in panels C, D were analyzed using one-way ANOVA, followed by Tukey’s multiple comparisons test, **p < 0.01.

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