Fig. 8: Schematic model of the mechanism by which HORMAD1 functions to promote the malignant phenotypes of lung cancer cells. | Cell Death Discovery

Fig. 8: Schematic model of the mechanism by which HORMAD1 functions to promote the malignant phenotypes of lung cancer cells.

From: The cancer/testis antigen HORMAD1 mediates epithelial–mesenchymal transition to promote tumor growth and metastasis by activating the Wnt/β-catenin signaling pathway in lung cancer

Fig. 8

Aberrant HORMAD1 expression suppresses the degradation of cytosolic β-catenin and promotes nuclear β-catenin accumulation by regulating AKT/GSK-3β signaling to activate the Wnt/β-catenin pathway, accompanied with upregulation of downstream target genes and induction of EMT to promote tumor growth and metastasis in lung cancer.

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