Fig. 1: The structure of human YTH domain-containing proteins.

A Multiple sequence alignment of YTH domains of human YTHDF1-3, YTHDC1-2 by ESPript3. B The domain composition of YTHDF1-3, YTHDC1-2. The five proteins YTHDF1, YTHDF2, YTHDF3, YTHDC1, and YTHDC2 share a highly conserved YTH domain (Orange). YTH domain is located at the C-terminal region.