Table 1 Oncogenic/tumor-suppressive role of YTH domain-containing proteins in various human cancers.

Proteins	Role in diseases	Cancer	Intersection molecules and/or pathway	References
YTHDF1	OG/TS	LUAD	YAP; MALAT1-miR-1914-3p-YAP axis	[104, 113]
YTHDF1	OG	GC	Wnt/PI3K-AKT pathway; FZD7-β-catenin axis	[110, 111]
YTHDF1	OG	BC	ITGA6	[105]
YTHDF1	OG	CRC	TCF7L2/TCF4, c-MYC; Wnt/β-catemin	[38, 70, 144]
YTHDF1	OG	GBM	hsa-mir-346	[78]
YTHDF1	OG	CC	PDK4	[36]
YTHDF1	OG	HCC	FZD5	[111]
YTHDF1	TS	OM	HINT2	[39]
YTHDF1	OG	OSCC	METTL3/m6A/ YTHDF1/c-Myc axis	[43]
YTHDF1	OG	OC	EIFC3	[35]
YTHDF1	OG	PC	TRIM44	[145]
YTHDF2	OG/TS	LUAD	YAP	[113]
YTHDF2	OG	BC	SETD7/KLF4 axis	[57]
YTHDF2	OG	CC	LncRNA GAS5	[146]
YTHDF2	OG	CRC	LncRNA XIST, YPEL5; SOX4	[59, 147]
YTHDF2	OG	GBM	EGFR/SRC/ERK pathway	[52]
YTHDF2	TS	HCC	SOC2, EGFR, IL11, SERPINE2	[101, 112]
YTHDF2	OG	PDAC	YAP	[148]
YTHDF2	OG	AML	TNFRSF2	[149]
YTHDF2	OG	PC	METTL3/YTHDF2/LHPP/NKX3-1; MOB3B	[56, 74, 75]
YTHDF3	OG	BC	ITGA6	[105]
YTHDF3	OG	BRC	ST6GALNAC5, GJA1, EGFR	[130, 150]
YTHDF3	OG	CRC	GAS5-YAP-YTHDF3 axis;	[146]
YTHDF3	OG	HCC	Zeb1; ITGA6	[132, 151]
YTHDF3	OG	LUAD	MALAT1-miR-1914-3p-YAP axis	[104]
YTHDC1	OG	UCEC		[152]
YTHDC2	TS	LUAD	SLC7A11	[153]
YTHDC2	TS	CRC	HIF-1α	[154]

OG oncogene, TS tumor suppressor, LUAD lung adenocarcinoma, GC gastric cancer, BC bladder cancer, CRC colorectal cancer, GBM glioblastoma, CC cervical cancer, HCC hepatocellular carcinoma, OM ocular melanoma, OSCC oral squamous-cell carcinoma, OC ovarian cancer, PC prostate cancer, PDAC pancreatic ductal adenocarcinoma, AML acute myeloid leukemia, BRC breast cancer, UCEC uterine corpus endometrial carcinoma.

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