Fig. 4: Knockout of GSDMD attenuated immuno-response and reduced macrophages infiltration.
From: Pyroptosis executor gasdermin D plays a key role in scleroderma and bleomycin-induced skin fibrosis
A GO analysis of RNA-seq data of skin biopsies of GSDMD KO and WT mouse skin after treated with BLM, n = 2. B, C RNA-seq data demonstrated CXCLs, CCLs, CCRs, MMPs, CD68, CD14, CSF1r, IL-1β, FN1, and IRF7 were down regulated. D Immunofluorescence analysis using anti-F4/80 for macrophages in BLM-treated mice skin, Scale bar: 100 μm. E Statistical analysis of the number of macrophages per high power field, results are mean ± SEM, (n = 3), **P < 0.01 (analyzed by t-test).
