Fig. 8: Illustration of the mechanisms of exosome GDF15 in inducing muscle atrophy.
From: GDF-15 in tumor-derived exosomes promotes muscle atrophy via Bcl-2/caspase-3 pathway
Exosomes derived from cachexic C26 cells containing abundant GDF15 which could induce muscle wasting via activating Bcl-2/caspase-3-based apoptosis pathway in myocytes.
