Fig. 1: NOP is upregulated and predicts poor prognosis in HCC. | Cell Death Discovery

Fig. 1: NOP is upregulated and predicts poor prognosis in HCC.

From: The nociceptin receptor promotes autophagy through NF-kB signaling and is transcriptionally regulated by E2F1 in HCC

Fig. 1

A Venn diagram of the differentially expressed genes in three HCC datasets. B Boxplots of NOP mRNA expression in HCC (n = 38) and adjacent tissue (n = 19) in the Mas Liver dataset. C Kaplan–Meier analysis based on NOP expression in the TCGA dataset (n = 360). D Boxplots of NOP mRNA expression in normal tissue (N) (n = 35), HCC (T) (n = 52), and adjacent tissue (NT) (n = 52) in the SYSUCC cohort. E IHC staining showing strong, moderate, and weak positive expression and negative expression of NOP in HCC. Scale bar: ×4 = 100 μm; ×40 = 10 μm. F Boxplots of the IHC score of NOP in HCC (n = 288) and adjacent tissue (n = 288).

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