Table 2 Univariate analysis of factors associated with OS and RFS in HCC patients (n = 288).

From: The nociceptin receptor promotes autophagy through NF-kB signaling and is transcriptionally regulated by E2F1 in HCC

Variables

Overall survival

Recurrence-free survival

HR

95% CI

Pa

HR

95% CI

Pa

Gender (female vs male)

0.670

0.324–1.385

0.279

0.576

0.301–1.102

0.096

Age (≤50 vs >50)

1.189

0.783–1.806

0.417

0.897

0.626–1.288

0.557

HBsAg (positive vs negative)

0.854

0.474–1.538

0.599

1.566

0.842–2.914

0.156

Child–Pugh classification (A vs B)

0.179

0.044–0.730

0.016

0.609

0.085–4.369

0.622

Serum AFP, ng/ml (≤20 vs >20)

1.662

1.070–2.580

0.024*

0.965

0.672–1.386

0.847

GGT, U/l (≤60 vs >60)

1.925

1.269–2.920

0.002*

1.707

1.189–2.451

0.004*

ICGR15 ≤10% vs >10%)

0.970

0.502–1.874

0.928

1.501

0.896–2.513

0.123

AST, U/l (≤40 vs >40)

1.380

0.906–2.101

0.134

1.646

1.144–2.367

0.007*

ALT, U/l (≤40 vs >40)

1.720

1.133–2.610

0.011*

1.657

1.154–2.380

0.006*

Tumor number (single vs multiple)

2.104

1.331–3.325

0.001*

1.826

1.191–2.799

0.006*

Tumor size, cm (≤5 vs >5)

1.419

0.935–2.155

0.100

1.583

1.100–2.276

0.013*

Microsatellite formation (no vs yes)

2.474

1.526–4.010

<0.001

2.845

1.826–4.433

<0.001*

Tumor capsule (no vs yes)

1.039

0.642–1.682

0.876

1.159

0.769–1.747

0.480

Vascular invasion (no vs yes)

1.988

1.209–3.269

0.007*

1.253

0.772–2.033

0.361

Intraoperative blood loss, ml (≤400 vs >400)

0.952

0.573–1.581

0.848

1.316

0.873–1.983

0.190

blood transfusion, mL (≤400 vs >400)

3.079

1.248–7.599

0.015*

0.743

0.184–3.010

0.678

Resection margin, cm ≤1 vs >1)

0.639

0.388–1.052

0.078

0.769

0.513–1.152

0.202

Cirrhosis (absent vs present)

1.282

0.772–2.130

0.337

1.256

0.817–1.930

0.299

Tumor differentiation (I/II vs III/IV)

1.778

1.145–2.760

0.010*

1.465

0.980–2.192

0.063

TNM stage (I vs I/III)

2.514

1.652–3.824

<0.001*

1.715

1.189–2.472

0.004*

NOP expression (high vs low)

2.160

1.333–3.501

0.002*

1.607

1.088–2.375

0.017*

  1. *Statistical significance was set to P < 0.05.
  2. aCox proportional hazards regression model.
Back to article page