Fig. 2: Second-line chemotherapy reverses resistance to first-line chemotherapy of GC. | Cell Death Discovery

Fig. 2: Second-line chemotherapy reverses resistance to first-line chemotherapy of GC.

From: Targeting IL8 as a sequential therapy strategy to overcome chemotherapy resistance in advanced gastric cancer

Fig. 2

A Schematic representation of the BGC823-bearing model of sequential chemotherapy resistance. B The growth curves of tumor (n = 12 per group). C Kaplan–Meier survival curve after 5-Fu plus oxaliplatin or paclitaxel treatments. *P < 0.05. D–H Blood routine index (WBC, NEU%, RBC, HGB, and PLT) were measured. Data are mean ± standard deviation. *P < 0.05, **P < 0.01, ***P < 0.001. I–M Blood biochemical index (ALT, AST, DBIL, UA, and LDH) were measured. Data are mean ± standard deviation. *P < 0.05. N, O The representative images of tumor, liver, kidney, spleen, heart and lung by H&E staining. N Scale bars, 2000 μm, O Scale bars, 50 μm.

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