Fig. 8: IGF2BP3 promote E2F3 mRNA stability via LINC00958. | Cell Death Discovery

Fig. 8: IGF2BP3 promote E2F3 mRNA stability via LINC00958.

From: IGF2BP3 enhances the mRNA stability of E2F3 by interacting with LINC00958 to promote endometrial carcinoma progression

Fig. 8

A, B Prolonged E2F3 mRNA half-life by overexpressing LINC00958 in EC cells. C, D Shortened E2F3 mRNA half-life by knocking down IGF2BP3 in EC cells. E, F Silencing LINC00958 partially counteracted the improved mRNA stability of E2F3 caused by overexpression of IGF2BP3 in EC cells. G, H RT–qPCR assays showed E2F3 expression levels in IGF2BP3–overexpressing EC cells combined with E2F3-silenced expression. I Schematic diagram created with BioRender.com illustrating the role of LINC00958 and IGF2BP3 in EC cells. *P < 0.05, **P < 0.01, ***P < 0.001. Data, mean ± S.D. All experiments were independently repeated with at least three replicates.

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