Fig. 3: FAM126A induces PC progression. | Cell Death Discovery

Fig. 3: FAM126A induces PC progression.

From: FAM126A interacted with ENO1 mediates proliferation and metastasis in pancreatic cancer via PI3K/AKT signaling pathway

Fig. 3: FAM126A induces PC progression.The alternative text for this image may have been generated using AI.

A The amounts of cell cycle-related proteins in FAM126A-silenced or overexpressing cells were examined by immunoblot, with GAPDH for normalization. B Phosphorylated PI3K and Akt amounts in PANC‑1 and BxPC‑3 cells were examined by immunoblot. C In GEPIA2, FAM126A was positively correlated with the EMT-associated transcription factor Snail (R = 0.51, P < 0.001) and Vimentin (R = 0.6, P < 0.001) in PC tissue samples. D Mesenchymal biomarkers, i.e., N-cadherin, Vimentin, and Snail, were downregulated significantly in FAM126A knockdown cells, while the epithelial marker E-cadherin was upregulated. FAM126A overexpression downregulated E-cadherin, while increasing N-cadherin, Vimentin, and Snail amounts. The internal control was GAPDH. *P < 0.05 **P < 0.01, ***P < 0.001.

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