Fig. 4: Effects of FAM126A on PC cell proliferation, migration, and invasion in vivo. | Cell Death Discovery

Fig. 4: Effects of FAM126A on PC cell proliferation, migration, and invasion in vivo.

From: FAM126A interacted with ENO1 mediates proliferation and metastasis in pancreatic cancer via PI3K/AKT signaling pathway

Fig. 4: Effects of FAM126A on PC cell proliferation, migration, and invasion in vivo.The alternative text for this image may have been generated using AI.

A sh-NC, sh-FAM126A#1, and sh-FAM126A#3 cells were administered by the subcutaneous route to three groups of mice for xenograft model establishment. After 6 weeks, xenografts were extracted and imaged. B Tumor volumes were assessed weekly for 42 days. C Upon euthanasia, tumors were weighed. D IHC showing Ki67 and PCNA protein amounts in tumor samples. E Liver metastatic tumor model establishment was performed via injection of PC stable cell suspensions into the mouse spleen. F Representative images of liver specimens. Arrow, metastatic tumor. G H&E staining of liver metastatic nodules in various groups. *P < 0.05 **P < 0.01, ***P < 0.001.

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