Fig. 6: AQP4 inhibitor TGN-020 alleviates experimental colitis in mice. | Cell Death Discovery

Fig. 6: AQP4 inhibitor TGN-020 alleviates experimental colitis in mice.

From: MTA1 aggravates experimental colitis in mice by promoting transcription factor HIF1A and up-regulating AQP4 expression

Fig. 6

A The statistic analysis for the changes in mouse weight after treatment with TGN-020. B The colon length of the mice after treatment with TGN-020. C HE staining to observe the pathological changes of colon tissues in TGN-020 treated mice (200×). D Statistical scoring results. E Graphical quantification of the colon wall thickness. F TUNEL staining analysis the apoptosis of colon epithelial cells in TGN-020 treated mice. G Immunohistochemistry of the expression of CD45 and AQP4. *p < 0.05. The measurement data were expressed as mean ± standard deviation. Data between two groups were compared by the unpaired student’s t test, and data among multiple groups were compared by one-way ANOVA, followed by Tukey’s post hoc tests. The experiment was conducted three times independently. n = 8; ***p < 0.001.

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