Fig. 5: Ectopic tRiMetF31 inhibited the migration and angiogenesis of breast cancer cells.

A, B HCC1806 (A) and MCF7 (B) cells grown in 6-well plates were transfected with either 50 nM or 25 nM WT-tRiMetF31 or Scr-tRiMetF31_2; at 22 h after transfection, the cells were treated with mitomycin C for 2 h, and a wound-healing assay was then performed. C Tube-formation assay was carried out using 50% of 48 h conditioned medium from either HCC1806 or MCF7 cells transfected with either 50 nM or 25 nM WT-tRiMetF31 or Scr-tRiMetF31_2 as detailed in the “Materials and methods”. * indicates P < 0.05.