Fig. 1: CircEIF3H is upregulated in breast cancer tissues and associated with poor prognosis. | Cell Death Discovery

Fig. 1: CircEIF3H is upregulated in breast cancer tissues and associated with poor prognosis.

From: CircEIF3H-IGF2BP2-HuR scaffold complex promotes TNBC progression via stabilizing HSPD1/RBM8A/G3BP1 mRNA

Fig. 1

A Heat maps showing the top differentially expressed circRNAs in three breast cancer samples compared to their adjacent normal tissues. B Length distribution of identified circRNAs in three paired breast cancer tissues and adjacent normal tissues. C Volcano plots showing the expression profiles of circRNAs. D Schematic illustrations showed the genomic loci of circEIF3H. circEIF3H was produced by exons 3 to 5 of the EIF3H gene. E Back-splice junction of circEIF3H identified by Sanger sequencing. F RNA fluorescence in situ hybridization for circEIF3H. Nuclei were stained with DAPI. G The expression level of circEIF3H in 70 pairs of breast cancer tissues and adjacent normal breast tissues. The bar chart presented the log2FC. H, I Expression level of circEIF3H in a different subtype of breast cancer. J, K Kaplan–Meier analysis showed the association between circEIF3H expression and overall survival of breast cancer patients (n = 196) (J) or TNBC patients (n = 98) (K).

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