Table 3 lncRNAs function as ceRNAs in pancreatic cancer.
From: The role of lncRNA-mediated ceRNA regulatory networks in pancreatic cancer
LncRNA | Role in PC | miRNA | Target | Function and mechanism | References |
|---|---|---|---|---|---|
SNHG12 | Oncogenic | miR-320b | ZEB | Promotes cell proliferation, invasion, and EMT | [95] |
KTN1-AS1 | Oncogenic | miR-23b-3p | HMGB2 | Enhances proliferation and invasion ability, while inhibits apoptosis | [98] |
PCED1B-AS1 | Oncogenic | miR-411-3p | HIF-1α | Promotes cell proliferation, invasion as well as EMT | [102] |
HCG11 | Oncogenic | miR-579-3p | MDM2 | Accelerates cell growth, enhances mobility, and inhibits apoptosis by activating the Notch/Hes1 signaling | [3] |
TP73-AS1 | Oncogenic | miR-128-3p | GOLM1 | Promotes pancreatic cancer growth and metastasis | [112] |
THAP9-AS1 | Oncogenic | miR-484 | YAP | Positive regulation of tumor growth and survival | [113] |
MIR31HG | Oncogenic | miR-193b | – | Positive regulation of tumor growth and survival | [114] |
MALAT1 | Oncogenic | miR-217 | KRAS | Positive regulation of tumor growth and survival | [115] |
AFAP1-AS1 | Oncogenic | miR-384 | ACVR1 | Induces pancreatic cancer stem cell maintenance | [116] |
LINC00511 | Oncogenic | miR-29b-3p | VEGFA | Modulates angiogenesis | [117] |
DLEU2L | Tumor suppressor | miR-210-3p | BRCA2 | Alleviates chemotherapy resistance of gemcitabine via inactivation of the AKT/mTOR signaling pathway | [118] |
LINC01111 | Tumor suppressor | miR-3924 | DUSP1 | Suppresses tumorigenesis, growth, and metastasis via inactivation of the SAPK/JNK signaling pathway | [125] |
GAS5 | Tumor suppressor | miR-221 | SOCS3 | Suppresses cell proliferation, invasion, migration, and gemcitabine resistance by inhibiting EMT and the JAK2/STAT3 signaling | [127] |
