Fig. 4: Effect of VEN incubation on gene expression of apoptotic signaling cascades in SEM (upper panel) and RS4;11 cells (lower panel). | Cell Death Discovery

Fig. 4: Effect of VEN incubation on gene expression of apoptotic signaling cascades in SEM (upper panel) and RS4;11 cells (lower panel).

From: Effective tumor cell abrogation via Venetoclax-mediated BCL-2 inhibition in KMT2A-rearranged acute B-lymphoblastic leukemia

Fig. 4

Gene expression was assessed by targeted RNA sequencing and analyzed using Transcriptome Analysis Console 4.0 software. The WikiPathways plugin was applied to generate pathway maps of genes involved in apoptotic signaling. Green and red colored gene boxes indicate up- and down-regulation following VEN incubation, respectively and darker shades symbolize stronger effects. Genes with average of less than 50 total reads were excluded to justify biological significance (marked as filtered out).

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