Fig. 6: Immediate effects of VEN application on cell line-based xenograft models. | Cell Death Discovery

Fig. 6: Immediate effects of VEN application on cell line-based xenograft models.

From: Effective tumor cell abrogation via Venetoclax-mediated BCL-2 inhibition in KMT2A-rearranged acute B-lymphoblastic leukemia

Fig. 6

Four mice per study group and model system were euthanized directly after therapy cessation. A Peripheral blood (PB), bone marrow (BM), and spleen blast frequencies were assessed by flow cytometry. No tumor cells were detected in spleens of RS4;11-derived xenograft mice after VEN therapy. Mean ± SD; Mann–Whitney test. B Spleens were weighed and measured immediately after experiment termination. Mean ± SD; Mann–Whitney test. C Isolated BM or spleen cells were spun onto microscopic slides and Pappenheim stained. Four representative images per xenograft model and study group at 100x magnification.

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