Fig. 1: Hypoxia-induced oxaliplatin chemoresistance and enhanced HOTAIR expression in CRC. | Cell Death Discovery

Fig. 1: Hypoxia-induced oxaliplatin chemoresistance and enhanced HOTAIR expression in CRC.

From: HOTAIR/miR-1277-5p/ZEB1 axis mediates hypoxia-induced oxaliplatin resistance via regulating epithelial-mesenchymal transition in colorectal cancer

Fig. 1

A Dose-response inhibition of CRC cells (LoVo, HT-29, and HCT116) to oxaliplatin under normoxia or hypoxia conditions. The relative cell viability of CRC cells was detected by CCK-8 assay. B Comparison of HIF-1α protein level in CRC cells between hypoxia and normal treatments. C Changes in lncRNA expressions under hypoxic treatment in LoVo cells. D Comparison of HOTAIR expression in CRC tissues to normal tissues. E Kaplan–Meier survival curve of COAD cancer patients with different HOTAIR expression (high vs low).

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