Fig. 5: The biological function of PLOD3 in vitro.
From: PLOD3 contributes to HER-2 therapy resistance in gastric cancer through FoxO3/Survivin pathway
A PLOD3 expression was knocked down by lentivirus in N87 and SNU-216 cell lines, and knockdown efficiencies were validated by immune-blotting experiments. B, C Inhibitory effects of PLOD3 downregulation on the proliferation of PLOD3-high GC cells were validated by colony formation assays and MTT assays. D Inhibitory effects of PLOD3 downregulation on the migration and invasion capacities of PLOD3-high GC cells were validated by transwell assays. E The cell cycle variation after PLOD3 knockdown in GC cells line according to flow cytometry assays. F The expression levels of invasion and proliferation-related markers were assessed by western blot.
