Fig. 9: Schematic of the proposed mechanism by which RBM47 inhibits HCC progression.
From: RBM47 inhibits hepatocellular carcinoma progression by targeting UPF1 as a DNA/RNA regulator
As an RNA binding protein, RBM47 elevated UPF1 mRNA by binding to the UPF1 3’UTR to enhance its stability. Meanwhile, RBM47 directly bound to the promoter of UPF1 as a DNA binding protein to promote UPF1 transcription. Thus, RBM47 suppressed HCC progression by enhancing UPF1 as a DNA/RNA regulator. HCC Hepatocellular carcinoma, RBM47 RNA-binding motif protein 47, RBP RNA binding protein, UPF1 Up-frameshift 1, NMD nonsense-mediated RNA decay, TF transcription factor, IHC Immunohistochemistry, IF Immunofluorescence, RIP RNA immunoprecipitation, RPKM Reads Per Kilo bases per Million reads, ChIP Chromatin immunoprecipitation, pre-mRNA precursor mRNA, TSS transcription initiation site, RRM RNA recognition motif, AS alternative splicing.
