Fig. 3: The molecular mechanism involved in m6A modification of ncRNAs.
From: The role of N6-methyladenosine-modified non-coding RNAs in the pathological process of human cancer
Top: In the nucleus, m6A modification can regulate splicing, processing, stability, interacting with RNA-binding proteins (RBP), and nucleus export of ncRNAs. The m6A-modified lncRNA mediates gene remodeling. In the cytoplasm, m6A modification mediates ncRNA translation, stability, ceRNA function, and interacting with RBP. Extracellular m6A modification can regulate circRNA immunity. Bottom: The m6A modification could regulate the processing, maturation, and ceRNA function of miRNAs. The m6A modification could regulate the stability, RBP interaction, and ceRNA function of lncRNAs, and m6A-modified lncRNA could regulate gene remodeling. The m6A modification could regulate the splicing, stability, translation, immunity, RBP interaction, and ceRNA function of circRNAs.
