Table 1 Writers, erasers and readers of RNA m6A modification.
From: The role of N6-methyladenosine-modified non-coding RNAs in the pathological process of human cancer
Classification | Name | Roles | References (PMID) |
|---|---|---|---|
Writers | METTL5 | Ribosome 18 S m6A methyltransferase | 33357433/31328227 |
| Â | METTL16 | Catalytic subunit of m6A | 33671635 |
|  | ZCCHC4 | Ribosome 28 S m6A methyltransferase | 31799605/31695039 |
| Â | METTL3 | Catalytic subunit of m6A | 31520073/29789545 |
| Â | METTL14 | Stabilizes METTL3 by forming a heterodimer with METTL3, and assists in identification of substrate | 31520073/33611339 |
| Â | WTAP | Promotes m6A methyltransferase activity and localization in nuclear speckles | 24407421 |
| Â | KIAA1429 | Component of MTC | 33611339 |
| Â | ZC3H13 | Component of MTC | 29547716 |
| Â | RBM15/15B | Recruits MTC to specific RNA motif | 27602518 |
Erasers | FTO | Eliminates m6A by oxidation | 31520073/29789545/33611339 |
| Â | ALKBH5 | Eliminates m6A by oxidation | 31520073/29789545/33611339 |
Readers | YTHDC1 | Regulates splicing and subcellular localization of m6A-modified RNAs | 26876937/33505026 |
| Â | YTHDC2 | Regulates stability and translation of m6A-modified RNAs | 28809393/32150756 |
| Â | YTHDF1 | Regulates stability and translation of m6A-modified RNAs | 26046440/32492408 |
| Â | YTHDF2 | Regulates stability and translation of m6A-modified RNAs | 26046440/32492408/33023892 |
| Â | YTHDF3 | Regulates stability of m6A-modified RNAs | 32492408/28106072 |
| Â | IGF2BPs | Regulates stability, subcellular localization, and translation of m6A-modified RNAs | 29476152/32761127/33035345 |
| Â | HNRNPA2/B1 | Regulates processing and splicing of m6A-modified RNAs | 26321680/31320558 |
