Fig. 4: OTUD1 arrests nuclear translocation of YAP1 through deubiquitination and reduces the activity of YAP1. | Cell Death Discovery

Fig. 4: OTUD1 arrests nuclear translocation of YAP1 through deubiquitination and reduces the activity of YAP1.

From: Deubiquitylase OTUD1 confers Erlotinib sensitivity in non-small cell lung cancer through inhibition of nuclear translocation of YAP1

Fig. 4: OTUD1 arrests nuclear translocation of YAP1 through deubiquitination and reduces the activity of YAP1.

A Western blot analysis of YAP1 protein in the nucleus and cytoplasm of PC-9/ER cells overexpressing OTUD1. B Immunofluorescence detection of YAP1 localization in the PC-9/ER cells overexpressing OTUD1. C Western blot analysis of ANKRD1, CTGF and CYR61 proteins in PC-9/ER cells overexpressing OTUD1. D Ubiquitination level of YAP1 in PC-9/ER cells overexpressing OTUD1 detected by Co-IP assay. **p < 0.01, ***p < 0.001. Data are shown as mean ± standard deviation of three technical replicates. Data between two groups were compared by unpaired t test.

Back to article page