Fig. 1: Transcriptome analysis of livers in murine ALF models. | Cell Death Discovery

Fig. 1: Transcriptome analysis of livers in murine ALF models.

From: Inhibition of TWEAK/Tnfrsf12a axis protects against acute liver failure by suppressing RIPK1-dependent apoptosis

Fig. 1

A Volcano plot indicating DEGs between normal mice and ALF mice, n = 2 for each group. B KEGG pathway analysis of DEGs showing the top pathways that are upregulated or downregulated during ALF. C, D GSEA analysis of MAPK, TNF, apoptosis, and cytokine-cytokine receptor interaction signaling pathways. E, F qPCR analysis of indicated mRNA levels in livers of PBS-treated mice and ALF mice (n = 4; mean ± s.d.). P values were determined by Student’s t test (**P < 0.01; ***P < 0.001; ****P < 0.0001; ns, not significant). G Heatmap showing top list out of commonly upregulated genes between TAA or APAP-induced ALF. H Expression of TWEAK and Tnfrsf12a of whole liver lysates from PBS-treated controls and ALF mice, n = 2 for each group. GAPDH was used for normalization.

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