Fig. 4: FTO was down-regulated in LUAD samples and associated with clinical significance in LUAD patients. | Cell Death Discovery

Fig. 4: FTO was down-regulated in LUAD samples and associated with clinical significance in LUAD patients.

From: Down-regulated m6A reader FTO destabilizes PHF1 that triggers enhanced stemness capacity and tumor progression in lung adenocarcinoma

Fig. 4

A Box plot showing the differential FTO mRNA levels in normal and tumor samples. B Differential analysis of FTO levels in normal and tumor samples based on GSE81809 dataset. C Differential analysis of FTO levels in normal and tumor samples based on GSE68465 dataset. D–F Correlation analysis showing the underlying relationships between FTO levels and clinical phenotypes, including TP53-mutation status (D), lymphatic metastasis (E) and clinicalpathological stages (F). G–H Kaplan–Meier analysis with log-rank test showed that patients with low FTO had poorer OS outcomes relative to those with high FTO expressions based on TCGA-LUAD cohort (G) and combined pan-LUAD datasets (H). Bar = Mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.

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