Table 1 Expression characteristics and clinical significance of hnRNPA/B family in diverse cancers.

From: Heterogeneous nuclear ribonucleoprotein A/B: an emerging group of cancer biomarkers and therapeutic targets

Cancer type	HnRNPs	Expression	Role	Clinical correlation	Detection methods	Ref.
MNs	hnRNPA0	Downregulated	Anti-cancer	Pathologic differentiation	Database	[23]
MM	hnRNPA2/B1	Upregulated	Oncogenic	OS	qRT-PCR	[86]
Glioblastoma	hnRNPA2/B1	Upregulated	Oncogenic	Survival	Database, qRT-PCR	[81]
OSCC	hnRNPA1	Upregulated	Oncogenic	Clinicopathologic stages	IHC, western blot	[47]
HNSCC	hnRNPA2/B1	Upregulated	-	OS, DSS	Database	[158]
LC	hnRNPA1	Upregulated	Oncogenic	OS	IHC, western blot, qRT-PCR	[32, 33]
LC	hnRNPA2/B1	Upregulated	Oncogenic	Lung development, early diagnosis, TNM stage, survival	Database, IHC, western blot; northern blot	[75, 77, 93, 159]
BC	hnRNPA2/B1	Conflicting	Conflicting	Survival	IHC, mRNA-sqe, northern blot	[101, 106, 107, 160]
ESCA	hnRNPA0	Upregulated	Oncogenic	-	western blot	[31]
ESCA	hnRNPA2/B1	Upregulated	Oncogenic	Disease risk, TMN stage; survival;	Database, IHC	[91, 161]
GC	hnRNPA1	Upregulated	Oncogenic	-	Database, IHC, western blot	[162]
GC	hnRNPA2/B1	Upregulated	Oncogenic	Pathologic differentiation, survival	Database, IHC, western blot, qRT-PCR, proteomics technique	[82, 98]
CRC	hnRNPA0	Upregulated	Oncogenic	Tumor size	Database, qRT-PCR	[28]
	hnRNPA1	Upregulated	Oncogenic	Lymph node metastasis, UICC staging, differentiation, recurrence, survival	IHC, western blot, qRT-PCR, proteomics technique	[34, 35, 163]
	hnRNPA2/B1	Upregulated	Oncogenic	Lymph node metastasis, distant metastasis	IHC, western blot	[164, 165]
	hnRNPA3	Upregulated	-	-	Proteomic technique	[134]
PC	hnRNPA2/B1	Upregulated	Oncogenic	Lymph node metastasis, pathologic differentiation	IHC	[166]
HCC	hnRNPA1	Upregulated	Oncogenic	-	Fluorescent probe	[70]
	hnRNPA2/B1	Upregulated	Oncogenic	Pathologic differentiation, hepatitis virus infection, survival	Database, IHC, western blot, qRT-PCR	[80, 99, 167]
	hnRNPA3	Upregulated	Oncogenic	Tumor size, differentiation, cirrhosis, diagnosis	IHC	[133]
PCa	hnRNPA1	Upregulated	Oncogenic	Gleason score, lymph node metastasis, advanced tumor stage, positive surgical margin, early biochemical recurrence	IHC	[168]
PCa	hnRNPA2/B1	Upregulated	-	RFS	Database	[169]
OC	hnRNPA2/B1	Upregulated	Oncogenic	OS, PFS	Database	[92, 170]
ACC	hnRNPA2/B1	Upregulated	-	OS, EFS	Database	[171]
ccRCC	hnRNPA0	Upregulated	-	Pathologic differentiation, OS	Database	[26]
BCa	hnRNPA3	Upregulated	Oncogenic	Lymph node metastasis, PFS	IHC	[135]

MNs myeloid neoplasms, MM multiple myeloma, OSCC oral squamous cell carcinoma, HNSCC head and neck squamous cell carcinoma, LC lung cancer, BC breast cancer, ESCA esophageal carcinoma, GC gastric cancer, CRC colorectal cancer, PC pancreatic cancer, HCC hepatocellular carcinoma, PCa prostate cancer, OC ovarian cancer, ACC adrenocortical carcinoma, ccRCC clear cell renal cell carcinoma, BCa bladder cancer, OS overall survival, DSS disease-specific survival, UICC International Union against Cancer, RFS relapse-free survival, PFS progression-free survival, EFS event-free survival.

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Table 1 Expression characteristics and clinical significance of hnRNPA/B family in diverse cancers.

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