Fig. 6: Lnc5745 regulates p53-mediated cardiomyocyte apoptosis. | Cell Death Discovery

Fig. 6: Lnc5745 regulates p53-mediated cardiomyocyte apoptosis.

From: Long noncoding RNA NONMMUT015745 inhibits doxorubicin-mediated cardiomyocyte apoptosis by regulating Rab2A-p53 axis

Fig. 6: Lnc5745 regulates p53-mediated cardiomyocyte apoptosis.

a, b The expression levels of p53-related apoptosis pathway proteins in NMVCs transfected with the pCDNA3.1-lnc5745 vector for 24 h. c, d Lnc5745 overexpression affected the expression levels of p53-related apoptosis pathway proteins in NMVCs treated with DOX. e, f Lnc5745 affected the levels of p53 apoptosis pathway-related proteins in mouse models. g, h Rab2A increased cardiomyocyte apoptosis attenuated by lnc5745 under DOX treatment by activating the p53/BAX/c-caspase3/c-PARP pathway. The results are from three independent experiments, *P < 0.05. Variables are presented as the mean ± SD.

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