Fig. 2: Cpd16 ameliorates H2O2-provoked oxidative injury in osteoblasts. | Cell Death Discovery

Fig. 2: Cpd16 ameliorates H2O2-provoked oxidative injury in osteoblasts.

From: Nrf2 signaling activation by a small molecule activator compound 16 inhibits hydrogen peroxide-induced oxidative injury and death in osteoblasts

Fig. 2: Cpd16 ameliorates H2O2-provoked oxidative injury in osteoblasts.

Primary murine osteoblasts (A–F), human osteoblasts (G–J), or the MC3T3-E1 murine osteoblastic cells (K and L) were pretreated (for 2 h) with Cpd16 (5/25 μM), or plus H2O2 (400 μM) stimulation; ROS contents (the CellROX intensity assay, A, B, G, H, K, L), TBAR activity (C), JC-1 dye staining (D, E, I, J), and ssDNA contents (F) were measured. *P < 0.05 versus “C” cells. #P < 0.05 versus cells with H2O2 stimulation but “Veh” pretreatment. Scale bar = 100 μm.

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