Fig. 7: Cnga1Y509C/Y509C mice show secondary retinal morphological changes and degeneration of cone photoreceptors. | Cell Death Discovery

Fig. 7: Cnga1Y509C/Y509C mice show secondary retinal morphological changes and degeneration of cone photoreceptors.

From: Mutations within the cGMP-binding domain of CNGA1 causing autosomal recessive retinitis pigmentosa in human and animal model

Fig. 7

Representative BAF and OCT-A scans of the fundus (A) and retinal vasculature (B) showing accumulation of autofluorescent spots and altered vascular bed in the Cnga1Y509C/Y509C mouse fundus. Representative confocal images showing expression of peanut agglutinin (PNA; green) in retinal cross sections of wild-type (1 month postnatal (PM1); (C) and Cnga1Y509C/Y509C mouse retinas (D–H) at PM1, PM3, PM6, PM9 and PM12 demonstrating a degeneration of cone photoreceptors with age. Scale bars in B marks 200 µm. Scale bar in H marks 25 µm.

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