Fig. 6: pTau expression in primary rat cortical neurons and RA-differentiated SH-SY5Y cells treated with GA and exposed to XE-991. | Cell Death Discovery

Fig. 6: pTau expression in primary rat cortical neurons and RA-differentiated SH-SY5Y cells treated with GA and exposed to XE-991.

From: A new K+channel-independent mechanism is involved in the antioxidant effect of XE-991 in an in vitro model of glucose metabolism impairment: implications for Alzheimer’s disease

Fig. 6

A, C Quantification and B, D representative pictures of pTau expression. pTau was identified by immunofluorescence staining (A–D). Scale bar 50 µM. The intensity of fluorescence of pTau was reported as control percentage. Differences among means were evaluated by one-way ANOVA followed by Dunnett’s post hoc test. A F (2, 6) = 26.96. Each column depicts the mean ± S.E.M. of independent experiments (for each experimental group, 50–100 cells were analyzed). *Significant versus all groups (p < 0.0001 versus Ctl, p < 0.01 versus XE-991 + GA); **significant versus all groups (p < 0.01). C F (2, 12) = 43.43. Each column depicts the mean ± S.E.M. of five independent experiments (for each experimental group, 50–100 cells were analyzed). *Significant versus Ctl (p < 0.0001) and XE-991 + GA (p < 0.01); **significant versus Ctl (p < 0.001) and GA (p < 0.01).

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