Fig. 5: Analysis of transcriptome alterations in PRMT5 activity-inhibited hEnSCs. | Cell Death Discovery

Fig. 5: Analysis of transcriptome alterations in PRMT5 activity-inhibited hEnSCs.

From: Endometrial stromal PRMT5 plays a crucial role in decidualization by regulating NF-κB signaling in endometriosis

Fig. 5

A Heatmap of differentially expressed genes between GSK591-treated and solvent-treated hEnSCs (SC) or decidualized hEnSCs (dSC). B Volcano plot of significantly downregulated (green dots) and upregulated (red dots) genes in PRMT5 activity-inhibited dSC (GSK591_dSC) compared with dSC. C GO biological process enrichment analysis of differentially expressed genes between GSK591_dSC and dSC. D Venn diagram showing the overlap of differentially expressed genes among the two comparisons, E and heatmap of the 43 overlapping genes. F Subnetwork analysis of transcription factors and their target genes in the 43 differentially expressed genes associated with decidualization. G Transcription factor enrichment of the 43 differentially expressed genes associated with decidualization. H qRT–PCR analysis of the mRNA levels of TP53, FOXO1 and CREB1 in the mid-secretory phase eutopic endometrium from women with (EMT: n = 7) or without (normal: n = 7) endometriosis. *P < 0.05, ***P < 0.001, Student’s t-test.

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