Fig. 7: The clinical significance of the USP35/BRPF1 axis in activating tumor MVA signature in human PRAD.

A The representative IHC images showed that USP35 levels were significantly associated with the expression of BRPF1 and SREBP2 in human PRAD specimens. B The associations among USP35 and MVA metabolic signature were further supported in TCGA-PRAD samples.